iScience
Age-linked gene activity changes varied across mouse brain regions
An analysis of 108,062 cell nuclei from adult and aged mice found greater age-linked gene activity changes in the basal forebrain than the midbrain and brainstem.An analysis of 108,062 cell nuclei from adult and aged mice found greater age-linked gene activity changes in the basal forebrain than the midbrain and brainstem.
Cross-sectional studyMechanisms
Who was studiedAdult and aged mice, against midbrain cholinergic neurons
What changedAge-linked gene activity increases were region-specific for 186 basal forebrain genes and 261 brainstem genes, but none in the midbrain
The catchRegional differences could reflect motor versus projection neuron identities rather than different aging sensitivity