Serum testosterone

1. Fluorouracil decreases serum testosterone in mice.

   “Pharmacological induction of BER stress with 5-FU in young mice resulted in similar defects in testosterone levels, LC viability, and DNA integrity.”

   Animals

   Aging-Induced Downregulation of DNA Polymerase β Impairing Base Excision Repair Causes Testicular Dysfunction

   Reproductive sciences (Thousand Oaks, Calif.)·18 Mar 2026

More on Fluorouracil

1. POLB decreases serum testosterone in mice.

   “Pol β+/− mice exhibited reduced serum testosterone, lower BMD, LC depletion, and impaired sperm motility.”

   Animalsheterozygous knockout (Pol β+/−)

   Aging-Induced Downregulation of DNA Polymerase β Impairing Base Excision Repair Causes Testicular Dysfunction

   Reproductive sciences (Thousand Oaks, Calif.)·18 Mar 2026

More on POLB

1. Age decreases serum testosterone in humans (r2=0.02).

   “Testosterone demonstrated a gradual and weakly correlated (r2=0.02) decline with age (20-60 years).”

   Humansmales

   SUN-678 Age-related Decline In Serum Testosterone And Relationship To Adiposity: Implications For TRT

   ENDO 2025 abstract·22 Oct 2025

1. Serum testosterone is associated with visceral adipose tissue in humans.

   “Percent body fat (%BF) and visceral adipose tissue (VAT) obtained by DXA, increased with age and had a strong inverse curvilinear relationship to T”

   Humansmales

   SUN-678 Age-related Decline In Serum Testosterone And Relationship To Adiposity: Implications For TRT

   ENDO 2025 abstract·22 Oct 2025