There are 7 papers on serum spermidine in aging research: 1 trial and 4 observational studies in people, 1 in animals, 1 review.
7 papers study it4 more mention it5 findings
“Serum level of spermidine was significantly lower in TBI patients with severe pathological scores.”
- Human trial1
- Humans4
- Animals1
Interventions
2Aminoretinoic ester
downin humans1
1 study
Aminoretinoic ester
downin humans1
Aminoretinoic ester decreases serum spermidine in humans (one year after treatment, compared with placebo controls) (125.6 vs 162.4 ng/ml in controls).
“125.6 +/- 117.2 ng/ml in 64 patients with MEH by Aminoretinoic Ester”
Human trialone year after treatment, compared with placebo controlsone yearn = 64
Spermidine radioimmunoassay in monitor of precancerous lesions of esophagus
Zhonghua zhong liu za zhi [Chinese journal of oncology]
Anticancer B
downin humans1
1 study
Anticancer B
downin humans1
Anticancer B decreases serum spermidine in humans (one year after treatment, compared with placebo controls) (125.1 vs 162.4 ng/ml in controls).
“125.1 +/- 72.9 ng/ml in 62 patients with MEH treated by Anticancer B”
Human trialone year after treatment, compared with placebo controlsone yearn = 62
Spermidine radioimmunoassay in monitor of precancerous lesions of esophagus
Zhonghua zhong liu za zhi [Chinese journal of oncology]
Associations
3Stroke
upin humans1
1 study
Stroke
upin humans1
Serum spermidine raises the risk of stroke in humans (high serum spermidine level).
“but has been linked to an increased risk of stroke”
Reviewhigh serum spermidine level
SAT-818 Spermidine in Health and Diseases
ENDO 2025 abstract
Recurrence of acute myocardial infarction
downin humans1
1 study
Recurrence of acute myocardial infarction
downin humans1
Serum spermidine predicts recurrence of acute myocardial infarction in humans.
“In acute myocardial infarction, higher serum spermidine level predicts lower risk of recurrence.”
Review
SAT-818 Spermidine in Health and Diseases
ENDO 2025 abstract
Traumatic brain injury severity
downin humans1
1 study
Traumatic brain injury severity
downin humans1
Serum spermidine is associated with traumatic brain injury severity in patients with severe pathological scores.
“Serum level of spermidine was significantly lower in TBI patients with severe pathological scores.”
Humansin patients with severe pathological scores
Spermidine Exhibits Protective Effects Against Traumatic Brain Injury
Cellular and molecular neurobiology