Serum pro-inflammatory cytokine levels

There are 4 papers on serum pro-inflammatory cytokine levels in aging research: 1 trial in people, 3 in animals.

Biomarker

4 papers study it1 more mentions it4 findings

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  • Human trial1
  • Animals3

Interventions

3

Xanthurenic acid

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1 study
  1. Xanthurenic acid decreases serum pro-inflammatory cytokine levels in mice.

    “XA treatment decreased pro-inflammatory cytokines (TNF-α, IL-1, IFN-γ, IL-6) in serum.”

    Animals

    XANTHURENIC ACID (XA) TREATMENT IMPROVES OVERALL HEALTH IN AGED MICE

    GSA 2024 abstract

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Dexmedetomidine

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1 study
  1. Dexmedetomidine decreases serum pro-inflammatory cytokine levels in humans (medium- and high-dose groups on day 2 after surgery, compared with baseline).

    “On D2, TNF-α, L-1β and IL-6 recovered their baseline levels in medium- and high-dose DEX groups (P > 0.05) but remained elevated in the other two groups.”

    Human trialmedium- and high-dose groups on day 2 after surgery, compared with baselinemedium and high maintenance doses

    Effects of dexmedetomidine doses on postoperative cognitive dysfunction and serum β- amyloid and cytokine levels in elderly patients after spine surgery: a randomized controlled trial

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

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Pioglitazone

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1 study
  1. Pioglitazone decreases serum pro-inflammatory cytokine levels in mice (sepsis induced by intravenous injection of a lethal dose of Escherichia coli).

    “lowered serum pro-inflammatory cytokines (TNF-α, IL-12, IFN-γ)”

    Animalssepsis induced by intravenous injection of a lethal dose of Escherichia coli

    Pioglitazone improves phagocytic activity of liver recruited macrophages in elderly mice possibly by promoting glucose catabolism

    Innate immunity

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Upstream

1

fat-1

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1 study
  1. fat-1 decreases serum pro-inflammatory cytokine levels in mice.

    “Serum pro-inflammatory markers, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 were found lower in Fat-1 mice, as compared to that of WT mice.”

    Animalsserum5 months

    The fat-1 transgene in mice increases antioxidant potential, reduces pro-inflammatory cytokine levels, and enhances PPAR-gamma and SIRT-1 expression on a calorie restricted diet

    Oxidative medicine and cellular longevity

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