Xanthurenic acid

Intervention1 paper5 findings

  • Animals1

Outcomes

5

Apoptosis

downin mice1Very low certainty

1 study

  1. Xanthurenic acid inhibits apoptosis in mice.

    “Interestingly, XA treatment also correlated with decreased apoptosis (Caspase-3, Caspase-7) in muscle tissues”

    Animalsaged miceskeletal muscle

    XANTHURENIC ACID (XA) TREATMENT IMPROVES OVERALL HEALTH IN AGED MICE · GSA 2024 abstract · 31 Dec 2024

Apoptosis →

Cellular senescence

downin mice1Very low certainty

1 study

  1. Xanthurenic acid decreases cellular senescence in mice.

    “reduced senescence markers (p16, p21), and mitigated inflammation (IL1-β) in the muscles of aged mice.”

    Animalsaged miceskeletal muscle

    XANTHURENIC ACID (XA) TREATMENT IMPROVES OVERALL HEALTH IN AGED MICE · GSA 2024 abstract · 31 Dec 2024

Cellular senescence →

Muscle fiber size

upin mice1Very low certainty

1 study

  1. Xanthurenic acid increases muscle fiber size in mice.

    “Musculoskeletal analyses unveiled improved bone microarchitecture and increased muscle fiber size in XA-treated mice group.”

    Animalsaged miceskeletal muscle

    XANTHURENIC ACID (XA) TREATMENT IMPROVES OVERALL HEALTH IN AGED MICE · GSA 2024 abstract · 31 Dec 2024

Inflammation

downin mice1Very low certainty

1 study

  1. Xanthurenic acid decreases inflammation in mice.

    “The XA treatment decreased pro-inflammatory cytokines (TNF-α, IL-1, IFN-γ, IL-6) in serum.”

    Animalsaged miceserum

    XANTHURENIC ACID (XA) TREATMENT IMPROVES OVERALL HEALTH IN AGED MICE · GSA 2024 abstract · 31 Dec 2024

Inflammation →

Grip strength

upin mice1Very low certainty

1 study

  1. Xanthurenic acid improves grip strength in mice.

    “They displayed improved grip strength, locomotor activity, and increased endurance.”

    Animalsaged mice

    XANTHURENIC ACID (XA) TREATMENT IMPROVES OVERALL HEALTH IN AGED MICE · GSA 2024 abstract · 31 Dec 2024

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