Senescent vascular smooth muscle cells
Biomarker1 paper1 finding
- Animals1
Interventions
1Salvianolic acid a
downin mice1Very low certainty
1 study
Salvianolic acid a
downin mice1Very low certainty
Salvianolic acid a decreases senescent vascular smooth muscle cells in mice.
“SAA reduced the burden of senescent VSMCs, decreased the size of plaque, and increased the stability of the fibrous cap.”
Animalsin ApoE -/- mice on a high-fat diet
Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Latest
1Advanced ScienceAnimals
Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells
The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.