Senescent nucleus pulposus cells

1 paper

Animals1

Latest

4 in 12 months

Journal of Investigative Surgery29 Apr

Hsa_Circ_0036763 is a Prognostic Biomarker for Intervertebral Disc Degeneration and Affects the Senescence and Collagen Loss of Nucleus Pulposus Cells via miR-4741/RGSL1

Cohort study of 120 peopleCellular senescence

Nature Communications8 Apr

Lactate metabolism reprogramming through orthogonal tandem catalysis to reverse intervertebral disc degeneration

Experiments in animalsIntervertebral disc degeneration

Bioactive Materials9 Mar

Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting senescent nucleus pulposus cells and inhibiting ferroptosis against intervertebral disc degeneration

Experiments in animalsIntervertebral disc degeneration

International Journal of Biological Macromolecules9 Nov

Exosome-targeted injectable hydrogels for sustained DEPTOR delivery and delay of IDD via the mTORC1/SASP pathway

Experiments in ratsInterventions

Journal of Extracellular Vesicles20 Aug

USP5-Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation

Experiments in animalsInterventions

Advanced Science7 Jul

Human iPSCs Derived MSCs-Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration

Experiments in animalsInterventions

Bioactive Materials10 Apr

Exosomes derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by alleviating the senescence of nucleus pulposus cells through epigenetic modifications

Experiments in animalsInterventions

Bone Research13 Mar

Reprogramming to restore youthful epigenetics of senescent nucleus pulposus cells for mitigating intervertebral disc degeneration and alleviating low back pain

Experiments in animalsInterventions

Bone Research22 Nov

KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m⁶A modification of ATG4a to promote NPCs senescence and IVDD progression

Experiments in cellsHistone modification and chromatin remodelling

International Journal of Biological Sciences10 May

Dysfunction of STING Autophagy Degradation in Senescent Nucleus Pulposus Cells Accelerates Intervertebral Disc Degeneration

Experiments in miceAutophagy