Senescent neurons

4 papers1 finding

Humans1
Animals2

Interventions

1

LY-364947

downin mice1

1 study

LY-364947 decreases senescent neurons in mice.
“Treatment with LY-364947, a SMAD2 phosphorylation inhibitor, markedly reduced the number of senescent neurons”
Animalsin a mouse spinal cord injury modelspinal cord
Exacerbation of neuronal senescence after spinal cord injury: Role of the macrophage-derived transforming growth factor-β1-SMAD2 signaling axis
Neural regeneration researchJun 19, 2025

More on LY-364947

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9 in 12 months

bioRxivAug 20

Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer's Disease

Preprint: experiments in human cellsCellular senescence

bioRxivMay 21

Dasatinib–Quercetin May Reduce Senescence Markers, Without Senolysis or Seizure Modification, in a Mouse Model of Focal Cortical Dysplasia

Preprint: experiments in miceDasatinib + quercetin

Nature CommunicationsApr 7

ASO therapy rescues NOTCH2NLC GGC repeat expansion-induced genomic damage, 3D chromatin structural abnormalities, and senescence

Experiments in human cellsInterventions

Journal of EthnopharmacologyApr 7

A specific pilose antler peptide LVLVEAELRE ameliorates cognitive deficits in SAMP8 mice via Celsr2

Experiments in miceInterventions

Experimental NeurologyMar 24

Disentangling causality in brain aging: The complex interplay between glial senescence, neuroinflammation, and neurodegeneration

ReviewCellular senescence

ZenodoMar 19

The

Preprint: commentaryMechanisms

Ageing Research ReviewsJan 22

Evaluating senescence-targeted approaches in Alzheimer's Disease: What we know and what lies ahead

ReviewAlzheimer's disease

AAIC 2025 AbstractDec 24

Thalamus has the highest density of neurescent among human brain regions

Computational studyMechanisms

Brain ResearchNov 24

IGF2BP2-mediated m6A modification of IGF1R mRNA promotes neuronal senescence and cognitive decline in Alzheimer's disease

Experiments in miceCellular senescence

Aging CellOct 13

Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Cognitive Decline by Restoring Senescent Microglial Function via NF-κB-SREBP1 Pathway Inhibition

Experiments in animalsInterventions