AgingResearch.NewsJoin free

LY-364947

Intervention

1 paper3 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals1

Outcomes

3

Motor function

upin mice1

1 study

  1. LY-364947 improves motor function in mice.

    “mitigated tissue degeneration, and improved motor function recovery.”

    Animalsin a mouse spinal cord injury model

    Exacerbation of neuronal senescence after spinal cord injury: Role of the macrophage-derived transforming growth factor-β1-SMAD2 signaling axis

    Neural regeneration researchJun 19, 2025

Tissue degeneration

downin mice1

1 study

  1. LY-364947 decreases tissue degeneration in mice.

    “Treatment with LY-364947, a SMAD2 phosphorylation inhibitor, markedly reduced the number of senescent neurons, mitigated tissue degeneration”

    Animalsin a mouse spinal cord injury modelspinal cord

    Exacerbation of neuronal senescence after spinal cord injury: Role of the macrophage-derived transforming growth factor-β1-SMAD2 signaling axis

    Neural regeneration researchJun 19, 2025

Senescent neurons

downin mice1

1 study

  1. LY-364947 decreases senescent neurons in mice.

    “Treatment with LY-364947, a SMAD2 phosphorylation inhibitor, markedly reduced the number of senescent neurons”

    Animalsin a mouse spinal cord injury modelspinal cord

    Exacerbation of neuronal senescence after spinal cord injury: Role of the macrophage-derived transforming growth factor-β1-SMAD2 signaling axis

    Neural regeneration researchJun 19, 2025

More on Senescent neurons

Latest

Related