5 papers2 findings
Time-restricted feeding
downin humans1
Time-restricted feeding decreases senescent CD4+ T cells in humans.
“The frequency of circulating senescent CD4+ T cells was decreased”
Human trial16:8 TREperipheral blood30 daysn = 49
Redox biology9 Nov 2024
Senescence-associated secretory phenotype (SASP)
upin mice1
Senescent CD4+ T cells increase senescence-associated secretory phenotype (SASP) in mice.
“senescent CD4+ T cells exacerbate the release of senescence-associated secretory phenotype (SASP).”
Animalsin DPD micegingival tissue
Senescent CD4⁺ T Cells Drive Diabetic Periodontitis via JAK-STAT-ROS-p38 MAPK
Journal of dental research17 Dec 2025
Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.