Senescent CD8+ T cells

1. INTERLEUKIN-15 + thymosin alpha 1 decreases senescent CD8+ T cells in mice.

   “It reduced the proportion of senescent CD8+ T cells while expanding activated effector populations”

   Animalsorthotopic HCC modelcombination therapyliver

   IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8⁺ T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression

   Journal of gastroenterology and hepatology·26 Mar 2026

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1. Anti-tnf has no effect on senescent CD8+ T cells in humans.

   “Anti-TNF did not impact the T8sen proportion of RA and SpA patients.”

   Humansin RA and SpA patients3 months

   Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines

   Clinical and experimental immunology·21 Jan 2025

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1. FABP4 induces senescent CD8+ T cells in human cells.

   “adipocyte-derived factors (MATES) and oleic acid (OA)-the predominant fatty acid in OvCa ascites-promoted tumor-induced CD8+Tsen formation by enhancing fatty acid (FA) uptake via FABP4”

   Cellsin OvCa microenvironment

   Fatty acid uptake mediated by FABP4 promotes the formation of CD8⁺T cell senescence through lipid peroxidation in the adipocyte-rich microenvironment of Ovarian Cancer

   Oncogenesis·6 Feb 2026

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1. Immune-mediated inflammatory disease increases senescent CD8+ T cells in humans.

   “T8sen, but not T4sen, accumulated more in patients with IMIDs than in patients with lung cancer and healthy donors.”

   Humansin IMID patients compared to lung cancer patients and healthy donors

   Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines

   Clinical and experimental immunology·21 Jan 2025

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1. Senescent CD8+ T cells are associated with IP-10 in humans.

   “and high IP-10 in SjD patients.”

   Humansin SjD patients

   Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines

   Clinical and experimental immunology·21 Jan 2025

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1. Senescent CD8+ T cells are associated with IL-6 in humans.

   “T8sen were associated with high IL-6 in SpA patients”

   Humansin SpA patients

   Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines

   Clinical and experimental immunology·21 Jan 2025

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1. Cytomegalovirus infection is associated with senescent CD8+ T cells in humans.

   “CMV-seropositivity was associated with the accumulation of T8sen.”

   Humansin IMID patients

   Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines

   Clinical and experimental immunology·21 Jan 2025

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