Advanced Science
In cells, senescent fat stem cells transfer damaged mitochondria
Cell experiments showed that vesicles from senescent fat stem cells carried damaged mitochondria, disrupting mitochondrial balance and activating inflammatory signaling…Cell experiments showed that vesicles from senescent fat stem cells carried damaged mitochondria, disrupting mitochondrial balance and activating inflammatory signaling in spinal disc cells.
Human cell studyMitochondrion
Who was studied3 senescent adipose-derived stem cells, against normal ADSCs
What changedSenescent adipose stem cells released more damaged mitochondrial cargo in microvesicles than normal cells
The catchH2O2-induced senescence does not fully recapitulate chronological aging