SASP marker expression

There are 2 papers on SASP marker expression in aging research: 1 trial and 1 observational study in people. The newest story, Nov 2, 2026: “Piperlongumine slowed knee osteoarthritis progression in rats”.

Biomarker

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Tricuspid aortic valve thoracic aortic aneurysm

upin humans1

1 study
  1. Tricuspid aortic valve thoracic aortic aneurysm is linked with higher SASP marker expression in humans (compared with healthy thoracic aorta and bicuspid aortic valve aneurysm).

    “TAA-TAV specimens showed a significant difference in SASP-marker expression of IL-6, NF-κB, mTOR, and cell-cycle regulators”

    Humanscompared with healthy thoracic aorta and bicuspid aortic valve aneurysmaortic wall

    Impacts of Telomeric Length, Chronic Hypoxia, Senescence, and Senescence-Associated Secretory Phenotype on the Development of Thoracic Aortic Aneurysm

    International journal of molecular sciences

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Biochemical and Biophysical Research Communications

Piperlongumine slowed knee osteoarthritis progression in rats

In experiments, rats with induced knee osteoarthritis had less damage to the joint’s cushioning tissues and less inflammation when given piperlongumine.In experiments, rats with induced knee osteoarthritis had less damage to the joint’s cushioning tissues and less inflammation when given piperlongumine.