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Worsening frailty linked to death risk across blood pressure trends

The highest-frailty group had 1.65 times the death rate in China and 2.21 times in the US compared with the lowest-frailty group.The highest-frailty group had 1.65 times the death rate in China and 2.21 times in the US compared with the lowest-frailty group.

Independently estimated joint SBP–frailty profiles in CHARLS and HRS.
Preprint: cohort studyPopulations
Paper
medRxiv

Deprivation linked to poorer brain health in older Tanzanians

Each one-unit rise in deprivation score was linked to 4.83 more points on a depression symptom scale and lower scores on two thinking tests.Each one-unit rise in deprivation score was linked to 4.83 more points on a depression symptom scale and lower scores on two thinking tests.

Older adults cluster beneath a dark blue-green brain, flanked by smaller groups with lighter brains and clustered or sparse gray houses.
Preprint: cross-sectional · 1,054 peoplePopulations
Paper
BMC Public Health

Walking difficulties projected to rise in older adults in Finland

Among adults aged 75 and older, major walking limitations were projected to affect 35% by 2040, compared with 27% in 2024.Among adults aged 75 and older, major walking limitations were projected to affect 35% by 2040, compared with 27% in 2024.

Time trends from 2013 to 2024 and projections until 2040 for the prevalence (the upper panel) and the number of persons (the lower panel) with mobility limitations among men and women aged 55 and…
Cross-sectional · 132,427 peoplePopulations
Paper
bioRxiv

Protein deposits rise in the human brain’s fluid-producing cells

Across 77 human cases, the average share of cells with deposits was near zero until age 40 and exceeded 50% after age 70.Across 77 human cases, the average share of cells with deposits was near zero until age 40 and exceeded 50% after age 70.

Choroid plexus tissue has clustered dark protein deposits in its cells, beside a smaller deposit-free fold and groups of clear and deposit-filled cells.
Preprint: cross-sectional · 77 peopleMechanisms
Paper

Thursday, November 5