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Thursday, November 5

Advanced Science

Brain scan model flags Alzheimer’s risk in Chinese adults

Without retraining, the model scored 0.913 for distinguishing Alzheimer’s from normal cognition and identified 95.2% of Alzheimer’s scans in the Chinese cohort.Without retraining, the model scored 0.913 for distinguishing Alzheimer’s from normal cognition and identified 95.2% of Alzheimer’s scans in the Chinese cohort.

Figure from Advanced Science
Cohort · 474 peopleAlzheimer's disease
Paper
medRxiv

Estimated insulin sensitivity patterns linked to heart risk

Two observational cohorts followed 4,823 adults aged 45 or older, linking persistently low or declining estimates to higher heart and blood vessel disease risk.Two observational cohorts followed 4,823 adults aged 45 or older, linking persistently low or declining estimates to higher heart and blood vessel disease risk.

eGDR trajectory classes and distribution of cumulative average eGDR in the HRS and ELSA cohorts.
Preprint: cohort · 4,823 peopleBiomarkers
Paper

Wednesday, November 4

bioRxiv

Mice that looked older in photos were frailer and died sooner

Each 100-day increase in photographic age beyond actual age was linked to higher frailty scores by 0.12 standard deviations—a measure of variation in scores.Each 100-day increase in photographic age beyond actual age was linked to higher frailty scores by 0.12 standard deviations—a measure of variation in scores.

Dataset and pipeline.
Preprint: cohort studyBiomarkers
Paper
Nature Health

Smoking linked to most excess deaths in less-educated white adults

Smoking was linked to an estimated 63% of 3.2 million excess deaths among less-educated white adults, compared with expected deaths based on more-educated adults’…Smoking was linked to an estimated 63% of 3.2 million excess deaths among less-educated white adults, compared with expected deaths based on more-educated adults’ mortality declines.

Two-year moving average of age-standardized all-cause mortality rates in white adults by age group and years of education, 1992–2024.
Study in peoplePopulations
Paper
bioRxiv

High pancreatic precancer burden linked to type 2 diabetes

The 39 pancreas sections (10%) with unusually high precancer burden came disproportionately from human donors with type 2 diabetes and high blood pressure.The 39 pancreas sections (10%) with unusually high precancer burden came disproportionately from human donors with type 2 diabetes and high blood pressure.

Pancreatic tissue with crowded, folded abnormal ducts amid dense scar fibers and immune cells, beside a smaller region of sparse, orderly ducts.
Preprint: cross-sectional studyBiomarkers
Paper