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medRxiv

Physical stress burden linked to cancer before age 50

A case-control study estimated that physical stress burden accounted for 17.0% of the association between an environmental exposure score and exposure-related cancers…A case-control study estimated that physical stress burden accounted for 17.0% of the association between an environmental exposure score and exposure-related cancers diagnosed before 50.

A group of upright, faceless people stands between orderly pale cells and irregular dark cells with enlarged nuclei.
Preprint: case-control · 7,550 peopleMechanisms
bioRxiv

Fertilization can offset age-related egg changes in mice

Eggs from aged mice fertilized in the lab formed early embryos at rates comparable to young controls and developed without detectable impairment in young recipients.Eggs from aged mice fertilized in the lab formed early embryos at rates comparable to young controls and developed without detectable impairment in young recipients.

An early embryo cutaway with clustered inner cells sits beside eggs with sparse and dense protein flecks, a sperm, and a laboratory mouse.
Preprint: mouse studyReproductive system
bioRxiv

Imaging links kidney structure to molecular aging in rats

Image-based age estimates differed from actual ages by a mean absolute error of 0.78 months in rats excluded from model training.Image-based age estimates differed from actual ages by a mean absolute error of 0.78 months in rats excluded from model training.

Kidney tissue shows orderly blue-green tubules beside widened, damaged gray tubules with uneven lipid droplets, above a small laboratory rat.
Preprint: rat study · 32 ratsBiomarkers