Protein synthesis and degradation markers

1. Caloric restriction decreases protein synthesis and degradation markers in humans.

   “several markers of protein synthesis downstream of mTORC1 and protein degradation were significantly reduced in vesicle-enriched plasma”

   Human trialprediabetes; participants who achieved at least 12% weight lossseverely energy-restricted dietvesicle-enriched plasma8 weeksn = 44

   Short-Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study

   Aging cell·16 Jun 2025

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