Protein nitration

5 papers1 finding

Humans1
Animals2

Upstream

1

SHC1

upin mice1

1 study

SHC1 increases protein nitration in mice.
“low levels of ONOO− formation present in aged p66Shc(-/-) mouse brain prevent protein nitration, delaying the loss of biological functions characteristic of the aging process”
Animalsshown by p66Shc knockoutbrain
p66Shc Inactivation Modifies RNS Production, Regulates Sirt3 Activity, and Improves Mitochondrial Homeostasis, Delaying the Aging Process in Mouse Brain
Oxidative medicine and cellular longevityMar 12, 2018

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p66Shc Inactivation Modifies RNS Production, Regulates Sirt3 Activity, and Improves Mitochondrial Homeostasis, Delaying the Aging Process in Mouse Brain

Experiments in miceCellular homeostasis