Papers on PPARα

171 papers11 new in 30 days

Friday, August 12

Biochemical and Biophysical Research CommunicationsAug 12

Effects of a selective PPARα modulator, sodium-glucose cotransporter 2 inhibitor, and statin on the myocardial morphology of medaka nonalcoholic fatty liver disease model

Experiments in animalsStatins

Paper

Thursday, August 11

Evidence-based Complementary and Alternative MedicineAug 11

Effects of Resveratrol Against Induced Metabolic Syndrome in Rats: Role of Oxidative Stress, Inflammation, and Insulin Resistance

Experiments in 32 ratsResveratrol

Paper

Saturday, May 21

The Journal of Nutritional BiochemistryMay 21

Nicotinamide reprograms adipose cellular metabolism and increases mitochondrial biogenesis to ameliorate obesity

Experiments in miceInterventions

Paper

Saturday, May 14

Journal of Translational MedicineMay 14

SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism

Experiments in miceFatty acid β-oxidation

Paper

Saturday, March 19

Free Radical Biology & MedicineMar 19

Nicotinamide riboside promotes Mfn2-mediated mitochondrial fusion in diabetic hearts through the SIRT1-PGC1α-PPARα pathway

Experiments in miceNicotinamide riboside

Paper

Monday, March 7

Archives of Physiology and BiochemistryMar 7

Resveratrol attenuates against high-fat-diet-promoted non-alcoholic fatty liver disease in rats mainly by targeting the miR-34a/SIRT1 axis

Experiments in ratsResveratrol

Paper

Monday, December 13

Nature MetabolismDec 13

NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding

Experiments in miceSirtuin signaling

Paper

Sunday, November 28

LifeNov 28

PPARα Modulation-Based Therapy in Central Nervous System Diseases

ReviewInterventions

Paper

Wednesday, September 29

BiomedicinesSep 29

Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproductive-Aged Women Living with Overweight and Obesity

Randomized trial in 23 peopleOverweight

Paper

Saturday, September 11

Journal of Thermal BiologySep 11

Diet-altered body temperature rhythms are associated with altered rhythms of clock gene expression in peripheral tissues in vivo

Experiments in ratsMechanisms

Paper

Thursday, August 5

Journal of Proteome ResearchAug 5

PPARα and PPARγ Signaling Is Enhanced in the Brain of the Naked Mole-Rat, a Mammal that Shows Intrinsic Neuroprotection from Oxygen Deprivation

Experiments in naked mole-ratsPPAR signaling

Paper

Wednesday, June 16

Nature CommunicationsJun 16

Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling

Experiments in micePPAR signaling

Paper

Thursday, June 3

MoleculesJun 3

PPARα Agonist, MHY3200, Alleviates Renal Inflammation during Aging via Regulating ROS/Akt/FoxO1 Signaling

Experiments in ratsKidney

Paper

Tuesday, April 20

International Journal of Molecular SciencesApr 20

Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice

Experiments in animalsMechanisms

Paper

Wednesday, April 14

Scientific ReportsApr 14

SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways

Experiments in mouse cellsInterventions

Paper

Wednesday, March 24

TheranosticsMar 24

Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARα signaling

Experiments in micePPAR signaling

Paper

Thursday, March 18

Oxidative Medicine and Cellular LongevityMar 18

PPARα Targeting GDF11 Inhibits Vascular Endothelial Cell Senescence in an Atherosclerosis Model

Experiments in miceCellular senescence

Paper

Tuesday, March 2

Histology and HistopathologyMar 2

Defective expression of the peroxisome regulators PPARα receptors and lysogenesis with increased cellular senescence in the venous wall of chronic venous disorder

Case-control study of 35 peopleCellular senescence

Paper

Saturday, February 13

Phytotherapy ResearchFeb 13

The effects of resveratrol supplementation on PPARα, p16, p53, p21 gene expressions, and sCD163/sTWEAK ratio in patients with type 2 diabetes mellitus: A double-blind controlled randomized trial

Randomized trial in 71 peopleResveratrol

Paper

Thursday, November 19

Nature CommunicationsNov 19

Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting

Experiments in miceNLRP3 inflammasome

Paper

Wednesday, November 18

PhytomedicineNov 18

Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe-/-mice: role of SIRT1

Experiments in miceInterventions

Paper

NutrientsNov 18

Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm

ReviewMechanisms

Paper

Monday, November 16

Experimental GerontologyNov 16

2,4-Dihydroxyphenyl-benzo[d]thiazole (MHY553), a synthetic PPARα agonist, decreases age-associated inflammatory responses through PPARα activation and RS scavenging in the skin

Experiments in ratsSkin

Paper

Wednesday, November 4

International Journal of Molecular SciencesNov 4

PPARs and Microbiota in Skeletal Muscle Health and Wasting

ReviewMechanisms

Paper

Thursday, September 24

AgingSep 24

Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles

Experiments in ratsDietary restriction

Paper

Thursday, September 17

Aging CellSep 17

Aging-induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation

Experiments in miceFatty acid β-oxidation

Paper

Friday, September 11

bioRxivSep 11

NHR-49 Acts in Distinct Tissues to Promote Longevity versus Innate Immunity

Preprint: experiments in wormsMechanisms

Paper

Thursday, September 10

Applied Immunohistochemistry & Molecular MorphologySep 10

MHY2013 Modulates Age-related Inflammation and Insulin Resistance by Suppressing the Akt/FOXO1/IL-1β Axis and MAPK-mediated NF-κB Signaling in Aged Rat Liver

Experiments in ratsInsulin resistance

Paper

Friday, September 4

MetabolitesSep 4

Skeletal Muscle Angiopoietin-Like Protein 4 and Glucose Metabolism in Older Adults after Exercise and Weight Loss

Trial in peopleInterventions

Paper

Thursday, July 23

World Journal of HepatologyJul 23

Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling

Experiments in miceInterventions

Paper