Polyubiquitinated protein aggregates
Biomarker1 paper2 findings
- Animals1
Interventions
1Intermittent fasting
downin mice1Very low certainty
1 study
Intermittent fasting
downin mice1Very low certainty
Intermittent fasting decreases polyubiquitinated protein aggregates in mice.
“Lipid overload caused cardiomyocyte accumulation of polyubiquitinated protein aggregates containing desmin, a scaffolding intermediate filament protein, which intermittent fasting prevented.”
Animalscardiomyocyte lipid overloadheart
Impaired proteostasis is an early feature of the diabetic heart in humans and mice · bioRxiv · 3 Sep 2026 · Preprint
Associations
1Diabetes mellitus
upin human cells1
1 study
Diabetes mellitus
upin human cells1
Diabetes mellitus is associated with polyubiquitinated protein aggregates in human cells.
“Crucially, non-failing diabetic human hearts also exhibited protein aggregate pathology.”
Cellsnon-failing diabetic human heartsheart
Impaired proteostasis is an early feature of the diabetic heart in humans and mice · bioRxiv · 3 Sep 2026 · Preprint