POLK subcellular distribution
3 papers4 findings
- Animals3
Upstream
1Neuronal activity
upin mice1
1 study
Neuronal activity
upin mice1
Neuronal activity increases POLK subcellular distribution in mice (Increased nuclear levels and reduced cytoplasmic fraction).
“neuronal activity itself can lead to an increase in nuclear POLK levels and a reduction of the cytoplasmic fraction”
Animalsneuron
eLife13 May 2026
Associations
2Chronological age
mixedin cells2
2 studies
Chronological age
mixedin cells2
Chronological age is associated with POLK subcellular distribution in cells.
“With chronological age, there is a progressive and significant reduction of nuclear POLK with a concomitant accumulation in the cytoplasm”
Cellsneuron
eLife19 Feb 2026Preprint
Chronological age is associated with POLK subcellular distribution in cells.
“With chronological age, there is a progressive and significant reduction of nuclear POLK with a concomitant accumulation in the cytoplasm”
Cellsneuron
eLife8 Nov 2024Preprint
Neuronal activity
mixedin cells1
1 study
Neuronal activity
mixedin cells1
Neuronal activity is associated with POLK subcellular distribution in cells.
“neuronal activity itself can lead to an increase in nuclear POLK levels and a reduction of the cytoplasmic fraction.”
Cellsneuron
eLife8 Nov 2024Preprint
Latest
2 in 12 monthseLife
An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging neurons
Preprint: experiments in animalsMechanisms
eLife
An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging neurons
Preprint: experiments in animalsMechanisms