Nuclear POLK expression

GABAergic interneuron is associated with nuclear POLK expression in cells.

“Nuclear POLK expression is significantly higher in GABAergic interneurons compared to excitatory pyramidal neurons and lowest in non-neurons”

Cellscompared with excitatory pyramidal neurons and non-neuronsbrain

An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging neurons

eLife·19 Feb 2026Preprint