Nuclear Polk abundance

GABAergic interneuron is associated with nuclear Polk abundance in mice.

“Nuclear POLK expression is significantly higher in GABAergic interneurons (INs) compared to excitatory pyramidal neurons and lowest in non-neurons”

AnimalsGABAergic interneurons compared with excitatory pyramidal neurons and non-neuronsbrain

An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging mouse neurons

eLife·13 May 2026

Chronological age is associated with nuclear Polk abundance in mice.

“With chronological age, there is a progressive and significant reduction of nuclear POLK”

Animalsneuron

An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging mouse neurons

eLife·13 May 2026