Cytoplasmic Polk abundance

Microglial association with interneurons are associated with cytoplasmic Polk abundance in mice.

“INs associated with microglia have significantly higher levels of cytoplasmic POLK in old age.”

AnimalsGABAergic interneuron

An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging mouse neurons

eLife·13 May 2026

Cytoplasmic Polk abundance predicts brain tissue age in mice.

“a concomitant accumulation in the cytoplasm that is predictive of brain tissue age”

Animalsbrain

An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging mouse neurons

eLife·13 May 2026