2 papers3 findings
ADL maintenance or recovery
downin humans1
Physical frailty decreases ADL maintenance or recovery in humans (-26.5 percentage points (95% CI, -50.3 to -2.8)).
Humansin hip fracture cases, Fried score 0 vs 3
The Journal of frailty & aging15 Sep 2026
Fracture-associated excess ADL decline
no changein humans1
Physical frailty has no effect on fracture-associated excess ADL decline in humans (0.03 (95% CI, -0.28 to 0.34)).
Humansinteraction per criterion for ADL contrast after hip fracture
The Journal of frailty & aging15 Sep 2026
Cardiovascular disease
upin humans1HR 1.21
Physical frailty raises the risk of cardiovascular disease in humans (HR 1.21, 95% CI 1.20-1.22).
HumansCKM stages 0-3
Frontiers in cardiovascular medicine5 Aug 2026
National Institute on AgingUS$154.3kNational Cancer InstituteUS$168.5k
National Institute on AgingCalifornia Pacific Med Ctr Res InstituteUS$104.8k2024–2029
National Cancer InstituteUniversity of RochesterUS$168.5k2023–2028
National Institute on AgingBoston University Medical CampusUS$49.4k2025–2026
Physical frailty fell from 8.3% to below 2%, and mild cognitive impairment dropped from 42.6% to 31.3% over two years in 230 kidney transplant recipients.Physical frailty fell from 8.3% to below 2%, and mild cognitive impairment dropped from 42.6% to 31.3% over two years in 230 kidney transplant recipients.
In rural older adults, transition intensity from reversible cognitive frailty was 0.429 toward cognitive impairment alone and 0.291 toward physical frailty, versus 0.224…In rural older adults, transition intensity from reversible cognitive frailty was 0.429 toward cognitive impairment alone and 0.291 toward physical frailty, versus 0.224 toward further deterioration.