PD-1+ T cells

5 papers study it13 more mention it1 finding

Humans4
Animals1

Upstream

1

Older age

upin humans1

1 study

Older age increases PD-1+ T cells in humans.
“aged individuals also showed a higher frequency of PD-1+ cells and significantly diminished IFN-γ/PD-1 ratios among T lymphocytes upon SARS-CoV-2 peptide stimulation.”
Humansupon SARS-CoV-2 peptide stimulation in mild COVID-19PBMC
Distinct SARS-CoV-2 specific NLRP3 and IL-1β responses in T cells of aging patients during acute COVID-19 infection
Frontiers in immunologySep 18, 2023

Latest

3 papers in 12 months

NPJ AgingOct 14

Lactate worsened arthritis and bone erosion in animals

In animals with induced arthritis, blocking lactate transport reduced disease progression more effectively than blocking the body's own lactate production.In animals with induced arthritis, blocking lactate transport reduced disease progression more effectively than blocking the body's own lactate production.

Animal studyBones and joints

Frontiers in ImmunologyJun 11

Ligature-induced periodontitis in mice potentially accelerates CD4⁺ T-cell senescence and exacerbates rheumatoid arthritis

Experiments in miceCellular senescence

Laboratory Investigation; a Journal of Technical Methods and PathologyNov 16

Association Between CD4+/Programmed Cell Death 1+/CD153+ Cell Infiltration to the Aging Liver and Progression of Hepatic Steatosis in a Novel Metabolic Dysfunction-Associated Steatohepatitis Model Nishiura Mouse

Experiments in miceInflammation

International ImmunopharmacologyOct 28

Analysis of immune cell remodeling and functional alterations induced by aging and obesity in mice

Experiments in miceImmune response

Bioscience TrendsOct 27

Deciphering the nexus of aging and pan-cancer: Single-cell sequencing reveals microenvironmental remodeling and cellular drivers

ReviewExtracellular matrix remodeling

Redox BiologyAug 19

DRP1 downregulation impairs mitophagy, driving mitochondrial ROS and SASP production in rheumatoid arthritis CD4⁺PD-1⁺T cells

Study in peopleMitophagy

AIDSAug 8

Persistent immunological repercussions of late antiretroviral initiation in children with HIV

Cross-sectional study of 55 peopleMechanisms

Science Translational MedicineAug 6

Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease

Cohort study in peopleKidney

Frontiers in ImmunologyJul 2

Exploring the differential functions of circulating follicular helper T and peripheral helper T cells in rheumatoid arthritis based on metabolism patterns

Study in peopleBlood and immune system

VaccinesAug 31

Vaccination with Tozimameran Induces T-Cell Activation, but Not Senescent or Exhaustive Alterations, in Kidney Transplant Recipients

Cohort study of 39 peopleKidney