P16 and P21 expression

Biomarker

1 paper1 finding

  • Humans1

Associations

1

Primary biliary cirrhosis

upin humans1

1 study
  1. Primary biliary cirrhosis is associated with P16 and P21 expression in humans.

    “The expression of p16(INK4a) and p21(WAF1/Cip1) was increased corresponding to telomere shortening and gammaH2AX-DNA-damage-foci in the damaged small bile ducts in PBC.”

    HumansTelomere shortening and DNA-damage foci in damaged small bile ductsbiliary epithelial cells

    Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence

    Hepatology (Baltimore, Md.)1 Jul 2008

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Antioxidants & Redox Signaling

Protein loss caused senescence-like changes in lab-grown neurons

Experiments in models of neurons that regulate energy balance found cell enlargement and other senescence-like changes after researchers removed or reduced selenoprotein…Experiments in models of neurons that regulate energy balance found cell enlargement and other senescence-like changes after researchers removed or reduced selenoprotein T.

Experiments in miceCellular senescence