Down syndrome with AD neuropathology
1 finding
Effects
1P-tau epitopes
upin humans1
1 study
P-tau epitopes
upin humans1
Down syndrome with AD neuropathology increases p-tau epitopes in humans.
“Observed pThr181, pThr217, and pThr231 burdens were higher in DSAD compared to young DS and neurotypical controls.”
HumansDown syndrome with AD neuropathologyfrontal cortexn = 98
Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan
Acta neuropathologica22 Mar 2026