National Institute of Diabetes and Digestive and Kidney DiseasesUS$1.6mNational Institute of General Medical SciencesUS$925.5kNational Institute on AgingUS$795k
In a mouse experiment, the compound also prevented low blood sugar and reduced liver injury after loss of the enzyme blocked by statins.In a mouse experiment, the compound also prevented low blood sugar and reduced liver injury after loss of the enzyme blocked by statins.
In animal experiments, loss of the protein worsened bone degeneration, while restoring it eased osteoporosis caused by removal of the ovaries.In animal experiments, loss of the protein worsened bone degeneration, while restoring it eased osteoporosis caused by removal of the ovaries.
Who was studiedFemale mice with ovariectomy-induced osteoporosis, 5 weeks
What changedBone volume fraction was approximately 2.0-fold higher after endothelial TRX2 restoration in ovariectomized mice than with a control vector
The catchBone preservation was assessed only 5 weeks after injection
In 6-month-old genetically modified mice, deleting a bone-signaling gene prevented gains in bone density and spongy bone in males and reduced them in females.In 6-month-old genetically modified mice, deleting a bone-signaling gene prevented gains in bone density and spongy bone in males and reduced them in females.
A heart-relaxation measure stayed at 6.2 with dapagliflozin, versus 6.6 to 6.7 with placebo, in a 32-person randomized trial.A heart-relaxation measure stayed at 6.2 with dapagliflozin, versus 6.6 to 6.7 with placebo, in a 32-person randomized trial.