Osteoclast differentiation

2 papers

Animals2

Latest

27 in 12 months

Chinese Journal of Gerontology11 h

Regulatory mechanism of lncRNA DANCR targeting miR-19a-3p in osteoclast differentiation and its role in ovariectomy-induced osteoporosis in mice

Experiments in mouse cellsBones and joints

Pharmacological ResearchYesterday

Deleting a signaling protein limits bone loss in mice

In mice lacking ovaries to mimic estrogen loss, deleting the Camkk1 gene from bone-degrading cells attenuated the loss of spongy bone.In mice lacking ovaries to mimic estrogen loss, deleting the Camkk1 gene from bone-degrading cells attenuated the loss of spongy bone.

Experiments in cellsOxidative stress and ROS signalling

Nature Communications7 Oct

Targeting a cell regulator reduced bone loss in mice

In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.

Experiments in miceBones and joints

Biology26 Sep

Estrogen Suppresses Osteoclast Function and Cytoskeletal Remodeling via Modulation of the RhoA-Pkn3-c-Src Signaling Pathway in Ovariectomized Rats

Experiments in ratsEstrogen

FASEB Journal26 Sep

Baicalein Ameliorates Postmenopausal Osteoporosis With Iron Accumulation by Inhibiting Osteoclastogenesis via Nrf2 Activation

Experiments in micePostmenopausal osteoporosis

Calcified Tissue International16 Sep

Sigma Anti-bonding Calcium Attenuates Ovariectomy-Induced Bone Loss by Preserving Trabecular Microarchitecture and Suppressing Osteoclastogenesis

Experiments in miceBones and joints

Nutrients15 Sep

Bioactive Phytochemicals from Artocarpus integer Leaves Improve Bone-Related Outcomes in Ovariectomized Rats: An Integrated LC-HRMS, Network Pharmacology, and Experimental Study

Experiments in ratsBones and joints

International Immunopharmacology13 Sep

Gut microbiota-derived indole-3-propionic acid suppresses osteoclast formation by promoting IL-10⁺ Breg differentiation via AhR signaling

Experiments in miceInterventions

Chemosphere9 Sep

Phthalate exposure and osteoporosis: NHANES associations and integrative in silico prioritization of candidate molecular targets

Cross-sectional study of 8,273 peopleOsteoporosis

Frontiers in Endocrinology8 Sep

Senescent immune cells, inflammaging, and bone loss: therapeutic potential and translational challenges of senolytics in osteoporosis

ReviewSenolytics