NT5C expression

1. Psychiatric disorder decreases NT5C expression in silico (mean Z of -7.37).

   “The nucleotidase NT5C showed an even stronger negative pattern, with a mean Z of -7.37.”

   In silicoacross major depressive disorder, bipolar disorder, obsessive-compulsive disorder, and schizophrenia

   Polygenic Constraints on NAD⁺ Metabolism in Major Psychiatric Illness: Mechanistic Support for NMN Supplementation

   Figshare·30 Mar 2026Preprint

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