NAD(P)H

Biomarker

4 papers1 finding

  • Animals2
  • Cells2

Interventions

1

Metoprolol + simvastatin + citalopram + oxycodone + oxybutynin

downin mouse cells1

1 study
  1. Metoprolol + simvastatin + citalopram + oxycodone + oxybutynin decreases NAD(P)H in mouse cells (AUC > 0.94).

    “Modelling demonstrated that cells from young mice receiving polypharmacy had less NAD(P)H and increased porphyrin relative to cells from old control mice”

    Cellsrelative to old control micemesenchymal stromal cells9-10 weeks

    Ageing and Polypharmacy in Mesenchymal Stromal Cells: Metabolic Impact Assessed by Hyperspectral Imaging of Autofluorescence

    International journal of molecular sciencesMay 27, 2024

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Nature Metabolism

Linked metabolic disruptions halt division in human cells

An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the…An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the lab.

Human cell studyInterventions