5 papers2 findings
Senescence-associated secretory proteins
upin cells1
Senescence-associated secretory proteins increase CD38 expression in cells.
“inflammatory cytokines found in the supernatant from senescent cells (Senescence associated secretory proteins, SASP) induce macrophages to proliferate and to express CD38.”
Cellssenescent-cell supernatantmacrophage
bioRxiv (Cold Spring Harbor Laboratory)Apr 17, 2019Preprint
Age
upin rats1
age is associated with CD38 expression in rats.
“We also identified increased CD38 expression using WB with age in SHRSP and WKY.”
AnimalsSHRSP and WKYbrainmales
Frontiers in pharmacologyMay 31, 2022
In mice infected with Trypanosoma cruzi, treatment with the NAD+ precursor improved CD8+ T-cell function and reduced parasite burden in blood and skeletal muscle.In mice infected with Trypanosoma cruzi, treatment with the NAD+ precursor improved CD8+ T-cell function and reduced parasite burden in blood and skeletal muscle.
Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age.Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age.