Metoprolol + simvastatin + citalopram + oxycodone + oxybutynin
- 2 independent labs in 1 country
- Funders: Australian Research Council and 3 more
- Animals2
Outcomes
4Optical redox ratio
downin mouse cells1
1 study
Optical redox ratio
downin mouse cells1
Metoprolol + simvastatin + citalopram + oxycodone + oxybutynin decreases optical redox ratio in mouse cells.
“This polypharmacy regimen may have a more profound impact on MSCs than ageing, and can simultaneously reduce optical redox ratio (ORR) and increase porphyrin levels.”
Cellsmesenchymal stromal cells9-10 weeks
International journal of molecular sciencesMay 27, 2024
NAD(P)H
downin mouse cells1
1 study
NAD(P)H
downin mouse cells1
Metoprolol + simvastatin + citalopram + oxycodone + oxybutynin decreases NAD(P)H in mouse cells (AUC > 0.94).
“Modelling demonstrated that cells from young mice receiving polypharmacy had less NAD(P)H and increased porphyrin relative to cells from old control mice”
Cellsrelative to old control micemesenchymal stromal cells9-10 weeks
International journal of molecular sciencesMay 27, 2024
Wire hang time
downin mice1
1 study
Wire hang time
downin mice1
Metoprolol + simvastatin + citalopram + oxycodone + oxybutynin impairs wire hang time in mice.
“only in old females reduced wire hang time and cumulative behaviour and balance beam time and %walked (p < 0.05)”
Animalsdiet6-8 weeksfemales
Probing polypharmacy, ageing and sex effects on physical function using different tests
Fundamental & clinical pharmacologyJan 21, 2024
Grip strength
downin mice1
1 study
Grip strength
downin mice1
Metoprolol + simvastatin + citalopram + oxycodone + oxybutynin impairs grip strength in mice.
“Polypharmacy reduced grip strength in all subgroups (p < 0.05)”
Animalsin all subgroupsdiet6-8 weeks
Probing polypharmacy, ageing and sex effects on physical function using different tests
Fundamental & clinical pharmacologyJan 21, 2024