Myonuclei: aging research evidence

CellOct 16

Exercise reshaped gene activity across tissues in mice

An 8-week wheel-running experiment in mice examined 22 tissues and plasma, finding the largest gene-activity changes in skeletal muscle.An 8-week wheel-running experiment in mice examined 22 tissues and plasma, finding the largest gene-activity changes in skeletal muscle.

Mouse studyInterventions

Paper

PNASOct 16

Amyotrophic lateral sclerosis and aging share muscle changes in mice

An experiment comparing mice modeling the nerve disease with mice across the lifespan mapped shared and distinct patterns of gene activity in muscle.An experiment comparing mice modeling the nerve disease with mice across the lifespan mapped shared and distinct patterns of gene activity in muscle.

Mouse studyMuscle

Paper

bioRxivOct 2

Altered cell crosstalk marks muscle disuse recovery in older women

At seven days of recovery from disuse, older women exhibited 7,999 differentially expressed genes across muscle cell types compared to 1,548 in younger women.At seven days of recovery from disuse, older women exhibited 7,999 differentially expressed genes across muscle cell types compared to 1,548 in younger women.

Preprint: experiments in cellsMuscle

Paper

bioRxivAug 27