Myocardial fibrosis

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Animals1

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44 in 12 months

European Heart Journal Cardiovascular Pharmacotherapy1 h

Dapagliflozin did not improve heart relaxation in small trial

A heart-relaxation measure stayed at 6.2 with dapagliflozin, versus 6.6 to 6.7 with placebo, in a 32-person randomised trial.A heart-relaxation measure stayed at 6.2 with dapagliflozin, versus 6.6 to 6.7 with placebo, in a 32-person randomised trial.

Randomised trial in 29 patients with HFpEF, 13 weeks, against placeboDapagliflozin

Limit: Only 29 patients completed the protocol, limiting power to detect improved relaxation

Paper

Aging Cell15 Oct

Restoring a protein partly improves heart function in mice

Experiments in mice producing a progeria-linked protein in heart muscle cells found that restoring an RNA-marking protein partly reduced abnormal heart changes.Experiments in mice producing a progeria-linked protein in heart muscle cells found that restoring an RNA-marking protein partly reduced abnormal heart changes.

Experiments in Zmpste24−/− mice, 2 months, against AAV-cTnT-GFP-treated miceMechanisms

Limit: Reduced heart fibrosis does not directly demonstrate restored pumping function

Paper

Frontiers in Cardiovascular Medicine15 Oct

Pak1 overexpression is associated with mild concentric cardiac remodeling and favorable systolic and diastolic functional indices in transgenic mice

Experiments in miceExtracellular matrix remodelling

Paper

Frontiers in Cardiovascular Medicine14 Oct

Therapy-induced senescence in breast cancer and cardiovascular disease: a double-edged biological process

ReviewCellular senescence

Paper

Protein & Cell2 Oct

Mosaic Loss of the Y Chromosome: Mechanisms and Diseases

ReviewMechanisms

Paper

Histology and Histopathology28 Sep

Killifish exhibit distinct structural changes and fibrosis during cardiac aging

Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.

Experiments in killifishMechanisms

Paper

Toxicology and Applied Pharmacology28 Sep

Arsenic triggers heart senescence in mice while quercetin counteracts the damage

Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat cardiomyoblasts.Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat cardiomyoblasts.

Experiments in miceQuercetin

Paper

Journal of Visualized Experiments28 Sep

Treadmill Exercise is Associated with Intestinal Barrier and Cardiac Nlrp3 Gene Expression Changes in Diabetic Mice

Experiments in miceExercise

Paper

FASEB Journal28 Sep

Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance

The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.

Experiments in miceInterventions

Paper

Journal of Cardiovascular Development and Disease24 Sep

Exercise Training Across the Hypertensive Heart Disease Continuum: Clinical Evidence and Implications for Prescription

ReviewExercise

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Myocardial fibrosis

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