Microbial metabolites

Papers on microbial metabolites

263 papers26 new in 30 days

Friday, November 13

bioRxiv

Bile acid reduced bone loss in mice with ovaries removed

In a 45-day experiment, deoxycholic acid improved bone structure in mice whose ovaries had been removed to model bone loss after menopause.In a 45-day experiment, deoxycholic acid improved bone structure in mice whose ovaries had been removed to model bone loss after menopause.

A sturdy dark blue-green bone cross-section with dense struts and small cells sits beside a fragile gray bone with broken struts and a small mouse.
Preprint: mouse studyBone loss

Thursday, November 12

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Stem Cell Reports

Bile acid from gut microbes disrupts blood stem cells in mice

In mouse experiments, prolonged exposure to a gut microbial bile acid contributed to blood stem cell loss, while a high-fiber diet reduced age-associated decline.In mouse experiments, prolonged exposure to a gut microbial bile acid contributed to blood stem cell loss, while a high-fiber diet reduced age-associated decline.

Figure from Stem Cell Reports
Mouse studyInterventions

Wednesday, November 4

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Frontiers in Microbiology

Nicotinamide mononucleotide reduced lens stiffness in mice

Lens stiffness measured 11.9 kilopascals at the higher dose, versus 17.9 in mice with diet-induced metabolic syndrome given no active compound.Lens stiffness measured 11.9 kilopascals at the higher dose, versus 17.9 in mice with diet-induced metabolic syndrome given no active compound.

Experimental workflow and sample-processing chain.
Mouse study · 94 miceNicotinamide mononucleotide

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