Papers on methylation levels

442 papers12 new in 30 days

Friday, October 30

BMC GastroenterologyOct 30

Methylation-sensitive restriction endonuclease-based amplification assay for detecting DNA methylation in colorectal cancer: a cross-sectional study

Cross-sectional study of 274 peopleColorectal cancer

Paper

Monday, October 26

BMC MedicineOct 26

Endometriosis and linked ovarian cancer show opposite biological aging

Biological age was 16.92% higher than chronological age in endometriosis patients but 14.64% lower in patients with related ovarian cancer.Biological age was 16.92% higher than chronological age in endometriosis patients but 14.64% lower in patients with related ovarian cancer.

Chronological age distribution by group.

Case-control studyEndometriosis

Paper

Sunday, October 25

Journal of the American Heart AssociationOct 25

Genetic analysis links a blood enzyme to Alzheimer’s risk

Genetic analysis linked inhibition of a blood-pressure enzyme to higher Alzheimer’s odds, with an odds ratio of 1.10.Genetic analysis linked inhibition of a blood-pressure enzyme to higher Alzheimer’s odds, with an odds ratio of 1.10.

Mendelian randomizationAlzheimer's disease

Paper

EpigenomesOct 25

Markers of Biological Aging and Survival in Recurrent and Metastatic Head and Neck Cancer Patients Receiving Immunotherapy

Hazard ratios for the associations between the markers of biological aging and progression-free survival (A) and overall survival (B) in R/M HNSCC.

Cohort study of 100 peopleBiomarkers

Paper

Friday, October 23

Paediatric and Perinatal EpidemiologyOct 23

Cardiometabolic Complications in Pregnancy and Biological Ageing in the Offspring: A Systematic Review and Meta-Analysis

Meta-analysisHypertensive disorders of pregnancy

Paper

Zhonghua Liu Xing Bing Xue Za ZhiOct 23

A study on the effects of animal-based foods and TXNIP gene DNA methylation on the incidence of type 2 diabetes mellitus

Cohort study of 1,942 peopleType 2 diabetes

Paper

PLOS OneOct 23

Alu hypomethylation in ischemic stroke: Associations with selected clinical characteristics

The Alu sequence contains 133 bp with two CpG dinucleotides.

Cross-sectional study of 85 peopleIschemic stroke

Paper

Friday, October 16

Molecular and Cellular BiochemistryOct 16

The METTL3/LOXL2 axis participates in aberrant epithelial-fibroblast crosstalk and induces oral submucous fibrosis in rats

Experiments in ratsMETTL3

Paper

AnimalsOct 16

Innexin2 Regulates Limb Regeneration in Procambarus clarkii: Insights from Transcriptome and DNA Methylation Analyses

The limb regeneration process of Procambarus clarkii.

Experiments in model organismsDNA methylation

Paper

Wednesday, October 14

Environmental EpigeneticsOct 14

DNA marks may help track sun exposure in human skin

In a five-month intervention involving 42 people, sunscreen-treated arms showed smaller changes in DNA marks than the opposite arms under everyday conditions.In a five-month intervention involving 42 people, sunscreen-treated arms showed smaller changes in DNA marks than the opposite arms under everyday conditions.

Randomized trial · 42 peopleSun exposure

Paper

Tuesday, October 6

Frontiers in ToxicologyOct 6

Detection of cancer epigenetic alterations in a pilot cohort of workers exposed to TiO₂

Cohort study in peopleBiomarkers

Paper

International Journal of Legal MedicineOct 6

Age estimation from DNA methylation in sectioned pulp-free teeth

Cross-sectional study of 128 peopleBiomarkers

Paper

Monday, September 28

CancersSep 28

Raising H3K9 methylation curbs leukemogenesis in mice

Increasing histone 3 lysine 9 methylation reduced leukemogenesis in both young and aged murine cells.Increasing histone 3 lysine 9 methylation reduced leukemogenesis in both young and aged murine cells.

Disruption of H3K9 methylation in HSPCs results in a premature-aging pre-malignant phenotype.

Experiments in human cellsMechanisms

Paper

Saturday, September 26

GenesSep 26

Comparison of Four Bisulfite Conversion Kits and Their Effects on DNA Methylation Detection and Age Prediction

Boxplot of the 6-plex and 4-plex post-PCR concentrations (ng/µL) of the 50 ng cohort (DNA methylation standards and samples) across the four tested bisulfite conversion kits (Fast, Max, Gold, and…

Cohort study in peopleBiomarkers

Paper

Thursday, September 17

GeroScienceSep 17

Integration of methylome and transcriptome reveals age-associated signatures of stage-specific dynamics and regulatory remodeling in dogs

Experiments in dogsEpigenetic regulation of gene expression

Paper

Tuesday, September 1

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICSSep 1

Mechanistic Study on IRF7-mediated Regulation of Learning and Memory Function by Aerobic Exercise in Aged Mice

Experiments in 60 miceAerobic exercise

Paper

Friday, August 28

International Journal of CancerAug 28

Toward Objective Anal Cancer Screening: From Swab-Based Genome-Wide Methylation Marker Discovery to Novel Test Development

Cohort study of 204 peopleAnal cancer

Paper

Monday, August 10

medRxivAug 10

Intergenerational and life-course links between a cardiovascular health-related methylation score and early vascular changes

Preprint: cohort study of 1,432 peopleBiomarkers

Paper

medRxivAug 10

The Xella Clock: a female-specific epigenetic aging clock optimized for menstrual fluid and endometrial tissue

Preprint: cohort study of 66 peopleBiomarkers

Paper

Wednesday, July 29

Environmental EpigeneticsJul 29

Gene-specific DNA methylation responses to Pb²⁺ exposure in aged male zebrafish and associations with locomotor dysfunction

Experiments in zebrafishDNA methylation

Paper

Frontiers in ImmunologyJul 29

Age-linked DNA marking tied to brain and immune measures

An observational study of 72 adults aged 20–88 examined links between an aging-related DNA mark, brain responses and immune-cell activation.An observational study of 72 adults aged 20–88 examined links between an aging-related DNA mark, brain responses and immune-cell activation.

Cohort · 72 peopleBiomarkers

Paper

Tuesday, July 7

OSF PreprintsJul 7

The PRC2 DNA-methylation substrate of aging is a proliferation-linked mitotic clock, not an organ-margin substrate: a pre-registered cross-organ test of the Organ-Bifurcation hypothesis

Preprint: computational studyDNA methylation

Paper

Tuesday, June 30

Zhonghua Liu Xing Bing Xue Za ZhiJun 30

Identification and validation of plasma biomarkers for mild cognitive impairment based on mRNA N⁶-methyladenosine methylome analysis

Case-control study in peopleMild cognitive impairment

Paper

Sunday, June 28

HIV & AIDS ReviewJun 28

Impact of clinical status at the time of HIV diagnosis on intensity of epigenetic ageing in HIV-infected men treated with integrase inhibitors

Cohort study of 10 peoplePopulations

Paper

Saturday, June 27

Nature AgingJun 27

Human tissues share some age-linked patterns in DNA tags

A computational meta-analysis of more than 15,000 human methylation profiles across 17 tissues found both common and tissue-specific associations with age.A computational meta-analysis of more than 15,000 human methylation profiles across 17 tissues found both common and tissue-specific associations with age.

Meta-analysisMechanisms

Paper

Tuesday, June 23

Ecology and EvolutionJun 23

Brain DNA tags track age in self-fertilizing fish

Age predictions based on 40 DNA sites differed from known ages by a median of 28.7 days in fish younger than 900 days.Age predictions based on 40 DNA sites differed from known ages by a median of 28.7 days in fish younger than 900 days.

Cross-sectional studyBiomarkers

Paper

Saturday, June 20

bioRxivJun 20

A Network Approach to DNA Methylation Clocks

Preprint: computational studyBiomarkers

Paper

Wednesday, June 17

Clinical EpigeneticsJun 17

Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study

Cohort study of 1,554 peopleObesity

Paper

Monday, June 15

BurnsJun 15

HMGB1 release initiates burn wound healing delay via HMGB1-produced DNA gap reduction, promoting DNA damage-hypomethylation-senescence cascade

Experiments in ratsSkin

Paper

Friday, June 12

CancersJun 12

Weight training may ease immune aging signs in cancer survivors

A 10-week pilot study of eight cancer survivors and eight healthy exercise partners suggested that training may help normalize survivors’ immune-related molecular…A 10-week pilot study of eight cancer survivors and eight healthy exercise partners suggested that training may help normalize survivors’ immune-related molecular patterns.

Single-arm trial · 5 peopleResistance training

Paper