Median telomere length

1. ASTCOQ02 increases median telomere length in humans (placebo-controlled trial) (9.81 ± 0.82 kb to 10.28 ± 0.88 kb; p = 0.008).

   “Telomerase activation was evidenced by an increase in median telomere length (9.81 ± 0.82 kb to 10.28 ± 0.88 kb; p = 0.008)”

   Human trialplacebo-controlled trialsix monthsn = 40

   The Effect of Telomerase Activator ASTCOQ02 on Cognitive Factors in Middle-Aged Adults: A randomized Double-Bling Study

   Preprints.org·Feb 7, 2025Preprint

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1. Astragalus increases median telomere length in humans (healthy volunteers; compared with placebo).

   “Subjects taking ASTCOQ02 had significantly longer median (P = 0.01) and short TL (P = 0.004)”

   Human trialhealthy volunteers; compared with placebocapsules6 monthsn = 40

   ASTCOQ02, a natural telomerase activator, lengthens telomeres in humans in a middle-aged population A randomized, double-blind, placebo-controlled study

   Research Square·Oct 27, 2022Preprint

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1. TRF1 gene therapy showed no clear effect on median telomere length in mice.

   “although AAV9-TRF1 treatment did not significantly affect median telomere length”

   Animals

   Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span

   Aging cell·Sep 24, 2017

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1. Zen meditation is linked with higher median telomere length in humans (p = 0.005).

   “The meditators group had a longer MTL (p = 0.005) and a lower percentage of short telomeres in individual cells (p = 0.007) than those in the comparison group.”

   Humans

   Zen meditation, Length of Telomeres, and the Role of Experiential Avoidance and Compassion

   Mindfulness·Feb 22, 2016

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