Cell Reports
Myelin lipid buildup links to lysosomal defects in mice
Profiling lysosomal fractions from mouse cortex from 3 to 24 months revealed an accumulation of myelin-derived glycosphingolipids that was most pronounced in microglia.Profiling lysosomal fractions from mouse cortex from 3 to 24 months revealed an accumulation of myelin-derived glycosphingolipids that was most pronounced in microglia.
Experiments in miceLysosome