Creatine

Biomarker5 papers3 findings

Humans3
Animals2

Associations

3

Osteosarcopenia

upin humans1

1 study

Osteosarcopenia is associated with creatine in humans.
Humansosteosarcopenia vs osteoporosisserumn = 104
A distinct serum metabolic profile characterizes osteosarcopenia: identifying potential metabolic biomarkers · Frontiers in endocrinology · 14 Aug 2026

Osteosarcopenia →

Frailty

mixedin mice1

1 study

Creatine is associated with frailty in mice.
“Notably, we identify FAD and 4−hydroxyhippurate in females and ergothioneine and creatine in males as candidate metabolites associated with frailty.”
Animalsplasmamalesn = 25
METABOLOMICS BIOMARKERS FOR FRAILTY: A LONGITUDINAL STUDY OF AGING MICE · GSA 2024 abstract · 31 Dec 2024

Frailty index

mixedin mice1

1 study

Frailty index is associated with creatine in mice.
“Additionally, we identify many sex-specific metabolomic markers for frailty, including creatine for females and FAD for males.”
Animalsfemale-specificplasmafemales
TRANSLATIONAL BIOMARKERS FOR AGING AND FRAILTY: IMPORTANT SEX DIFFERENCES · GSA 2024 abstract · 31 Dec 2024

Frailty index →

Funding

National Cancer InstituteUS$652kNational Institute of Diabetes and Digestive and Kidney DiseasesUS$441.8k2 grants since 2023

Latest

28

International Journal of Developmental NeuroscienceReview3 Oct

REST in the Central Nervous System: Context-Dependent Regulation of Neuronal Homeostasis and Disease

Epigenetic regulation of gene expression

Experimental PhysiologyReview29 Sep

Musculoskeletal decay and bone-muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures

Bones and joints

European Journal of Applied PhysiologyHuman trial24 Sep

Comparing high-intensity resistance training incorporating periodic eccentric-only exercise with blood flow restriction training in older men: physiological responses and exercise feasibility

Resistance training

Research SquareHuman trialPreprint24 Sep

Strength training intervention with creatine/whey protein supplementation vs placebo on frailty in older adults with cirrhosis (STRIVE): A Randomized Controlled Trial

Resistance training

Cell Reports MedicineHumans23 Sep

A blood-based metabolic signature for earlier detection of lung cancer

Journal of the International Society of Sports NutritionReview21 Sep

Resistance training combined with creatine supplementation: a three-level meta-analysis of multidimensional outcomes from strength enhancement to body composition remodeling

Resistance training

Psychiatry Research NeuroimagingHumans16 Sep

Hippocampal magnetic resonance spectroscopy markers in late life anxiety - a preliminary report

JBMR PlusHumans9 Sep

Greater D₃-creatine muscle mass and MRI thigh muscle volume are associated with higher bone strength in older adults: exploratory findings in The Study of Muscle, Mobility and Aging (SOMMA)

Bones and joints

Frontiers in NutritionReview9 Sep

Effects of resistance training combined with creatine supplementation on muscle strength, physical function, and muscle mass in older adults: a systematic review and three-level meta-analysis

Resistance training

Nutrition, Metabolism, and Cardiovascular DiseasesReview8 Sep

Safety of lipid-lowering therapies: it is time for a "DOCebo" effect