Imaging biomarkers
Biomarker1 paper
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13Multimodal PET and MRI predict dementia with Lewy bodies
Combined occipito-parietal cortex pathology and striatal dopamine loss predicted conversion to dementia with Lewy bodies with a sub-distribution…Combined occipito-parietal cortex pathology and striatal dopamine loss predicted conversion to dementia with Lewy bodies with a sub-distribution hazard ratio of 38.68.
Deep learning matches experts in scoring aortic valve calcium
Algorithm scores correlated strongly with expert assessments at r = 0.99, identifying moderate-to-severe aortic stenosis with 0.92 sensitivity and…Algorithm scores correlated strongly with expert assessments at r = 0.99, identifying moderate-to-severe aortic stenosis with 0.92 sensitivity and 0.98 specificity.
CT biomarkers improve postoperative mortality prediction
Adding automated CT biomarkers to an ICD-based frailty score raised one-year mortality prediction AUROC from 0.75 to 0.79 in 7,638 surgery patients.Adding automated CT biomarkers to an ICD-based frailty score raised one-year mortality prediction AUROC from 0.75 to 0.79 in 7,638 surgery patients.
Brain small vessel disease links to stroke and mortality risk
Compared with a zero score, participants with cerebral small vessel disease scores of 1 and 2 had hazard ratios of 1.48 and 1.52 for adverse events.Compared with a zero score, participants with cerebral small vessel disease scores of 1 and 2 had hazard ratios of 1.48 and 1.52 for adverse events.
Microglia-derived extracellular vesicle content as a biomarker for early detection of Alzheimer's disease
Contralesional brain aging links to stroke aphasia severity
In 188 individuals with chronic stroke, regional deviations from normative brain aging in the undamaged hemisphere accounted for aphasia severity and…In 188 individuals with chronic stroke, regional deviations from normative brain aging in the undamaged hemisphere accounted for aphasia severity and predicted post-therapy recovery.