IFN-γ production by γδ T cells

1. SGLT2 inhibitors decrease IFN-γ production by γδ T cells in humans (approximately 40% reduction).

   “successful antidiabetic therapy was associated with a progressive reduction in IFN-γ production, reaching approximately 40% after 12 months”

   Human trialin patients with poorly controlled T2D12 monthsn = 25

   γδ T-cell interferon-γ production reflects metabolic improvement during SGLT2 inhibitor-based therapy in type 2 diabetes · Frontiers in endocrinology · 11 Sep 2026

SGLT2 inhibitors →

1. Type 2 diabetes is associated with IFN-γ production by γδ T cells in humans.

   “patients with T2D exhibited increased interferon-γ (IFN-γ) production by both Vδ1 + and Vδ2 + γδ T-cell subsets compared with controls”

   Humanscompared with controls at baseline

   γδ T-cell interferon-γ production reflects metabolic improvement during SGLT2 inhibitor-based therapy in type 2 diabetes · Frontiers in endocrinology · 11 Sep 2026

Type 2 diabetes →