HSD11B1 activity

1. Patient-derived serum has no effect on HSD11B1 activity in human cells.

   “Pro-inflammatory mediators such as TNFα directly upregulated 11β-HSD1 activity in myotubes, whilst sera from CKD donors did not.”

   Cellssera from chronic kidney disease donorspatient-derived seraprimary human myotube

   Divergent roles of skeletal muscle 11β-HSD1 in age-related and chronic kidney disease-associated sarcopenia

   European journal of endocrinology·30 Apr 2026

More on Patient-derived serum

1. TNF-alpha increases HSD11B1 activity in human cells.

   “Pro-inflammatory mediators such as TNFα directly upregulated 11β-HSD1 activity in myotubes, whilst sera from CKD donors did not.”

   Cellsprimary human myotube

   Divergent roles of skeletal muscle 11β-HSD1 in age-related and chronic kidney disease-associated sarcopenia

   European journal of endocrinology·30 Apr 2026

More on TNF-alpha

1. HSD11B1 activity predicts grip strength in humans.

   “Muscle 11β-HSD1 activity was not elevated with CKD, but increased with age (r = 0.559, P = .001), predicting lower grip strength (P = .008).”

   Humansskeletal muscle

   Divergent roles of skeletal muscle 11β-HSD1 in age-related and chronic kidney disease-associated sarcopenia

   European journal of endocrinology·30 Apr 2026

1. Age is associated with HSD11B1 activity in humans (r = 0.559).

   “Muscle 11β-HSD1 activity was not elevated with CKD, but increased with age (r = 0.559, P = .001), predicting lower grip strength (P = .008).”

   Humansquadriceps

   Divergent roles of skeletal muscle 11β-HSD1 in age-related and chronic kidney disease-associated sarcopenia

   European journal of endocrinology·30 Apr 2026