Among patients with obesity and heart failure with preserved ejection fraction, exercise pressure fell 9.8 millimeters of mercury with semaglutide versus a 0.9 rise with…Among patients with obesity and heart failure with preserved ejection fraction, exercise pressure fell 9.8 millimeters of mercury with semaglutide versus a 0.9 rise with placebo.
Semaglutide improved how much the heart’s upper left chamber stretched by 5.7 percentage points versus placebo over 52 weeks in a 49-person trial substudy.Semaglutide improved how much the heart’s upper left chamber stretched by 5.7 percentage points versus placebo over 52 weeks in a 49-person trial substudy.
In-hospital mortality was 37.1% in the high-frailty group versus 16.3% in the low-frailty group in a national database analysis.In-hospital mortality was 37.1% in the high-frailty group versus 16.3% in the low-frailty group in a national database analysis.
Within one year, frailty was linked to a 63% higher relative risk of death, hospitalization or specified heart complications compared with no frailty.Within one year, frailty was linked to a 63% higher relative risk of death, hospitalization or specified heart complications compared with no frailty.
Mice lacking the regulator developed high lung blood pressure by 8 months; right-heart pumping pressure exceeded 40 millimeters of mercury, compared with control mice.Mice lacking the regulator developed high lung blood pressure by 8 months; right-heart pumping pressure exceeded 40 millimeters of mercury, compared with control mice.
In a separate validation group, the model detected 82.1% of crises; 31.6% of positive predictions corresponded to a crisis.In a separate validation group, the model detected 82.1% of crises; 31.6% of positive predictions corresponded to a crisis.