Glutathione redox balance

1. Creatine + beta-hydroxy-beta-methylbutyrate improves glutathione redox balance in humans (P < 0.05).

   “creatine plus β-hydroxy-β-methylbutyrate supplementation preserved glutathione redox balance in older adults (all immunometabolic comparisons P < 0.05)”

   Reviewsupplementation

   Research Synthesis: Biomarker Effects — full paper

   Preprint·Jan 1, 2026

More on Creatine + beta-hydroxy-beta-methylbutyrate

1. Ovariectomy decreases glutathione redox balance in rats.

   “Glutathione redox balance (GSH/GSSG) was reduced in young ovariectomized, old controls, and old ovariectomized groups when compared with young controls, indicating an increased oxidative stress.”

   Animalsyoung ovariectomized rats compared with young controlsheart9 weeksfemales

   Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress

   Clinical interventions in aging·Mar 22, 2016

More on Ovariectomy

1. Proteasome inhibition has no effect on glutathione redox balance in mouse cells.

   “Variations in glutathione-redox balance were also observed in SIPS and RS, and not in PIIPS.”

   Cellsproteasome inhibition-induced premature senescenceprimary lung fibroblasts

   Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli

   Age (Dordrecht, Netherlands)·Feb 11, 2016

More on Proteasome inhibition