Proteasome inhibition
Proteasome inhibition has been studied in 2 papers since 2016: none in people yet, 2 in cells. No study of it in people or animals has been published yet. The newest paper, Sep 2, 2022: “Adult fibroblasts use aggresomes only in distinct cell-states”.
2 papers study it3 findingsUpdated
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: National Institute of Neurological Disorders and Stroke and others
- Cells2
What did studies of Proteasome inhibition find?
3Studies of Proteasome inhibition measured 3 outcomes; the most studied are aggresome formation (1 study), glutathione redox balance (1) and cytokine secretion (1).
Aggresome formation
upin mouse cells1
1 study
Aggresome formation
upin mouse cells1
Proteasome inhibition induces aggresome formation in mouse cells.
“quiescent and immortalized fibroblasts formed aggresomes, whereas proliferating and senescent fibroblasts did not.”
Cellsin quiescent and immortalized adult mouse dermal fibroblasts
Adult fibroblasts use aggresomes only in distinct cell-states
Scientific reports
Glutathione redox balance
no changein mouse cells1
1 study
Glutathione redox balance
no changein mouse cells1
Proteasome inhibition has no effect on glutathione redox balance in mouse cells.
“Variations in glutathione-redox balance were also observed in SIPS and RS, and not in PIIPS.”
Cellsproteasome inhibition-induced premature senescenceprimary lung fibroblasts
Age (Dordrecht, Netherlands)
Cytokine secretion
upin mouse cells1
1 study
Cytokine secretion
upin mouse cells1
Proteasome inhibition increases cytokine secretion in mouse cells (13 of 62 analyzed cytokines increased).
“while SIPS and RS showed an increase in the secretion of most cytokines, and in PIIPS only 13 were incremented.”
Cellsproteasome inhibition-induced premature senescenceprimary lung fibroblasts
Age (Dordrecht, Netherlands)