Genomic stability

Papers on genomic stability

481 papers19 new in 30 days

Thursday, September 10

Integrative Biomedical ResearchSep 10

Cellular Reprogramming Strategies for Age-Related Macular Degeneration From iPSCs to In Vivo Therapy

ReviewPartial reprogramming

Friday, September 4

Frontiers in NutritionSep 4

EWAS in a polyphenol dense, DNA methylation-targeted, controlled diet and lifestyle study

Within-individual differentially methylated loci between baseline and week 8.

Non-randomized trial in 38 peopleInterventions

Tuesday, September 1

Le Mali MedicalSep 1

BRCA1 Gene's Mutations And Hereditary Breast Cancer: Genetic, Biological, And Clinical Aspects

ReviewMechanisms

Sunday, August 30

Aging CellAug 30

SIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin-Modifying Complexes

SIRT1 inhibits L1 retrotransposition by suppressing 5′‐UTR activity.

Experiments in human cellsTransposable element activity

Friday, August 28

Aging CellAug 28

Oxygenaging: A Physiological Framework for Geroscience

Oxygenaging: A Systems‐Level Physiological Framework and Organ‐Specific Manifestations.

ReviewMechanisms

Tuesday, August 25

Molecular NeurobiologyAug 25

Beyond the Ribosome: The Expanding Role of the Nucleolus in Neurodegenerative Pathways

The nucleolus as a comprehensive cellular stress sensor and response hub.

ReviewMechanisms

Monday, August 24

FASEB JournalAug 24

A Novel Role of DELTEX2 in Maintaining Genomic Stability of Granulosa Cells During Ovarian Aging

Experiments in human cellsReproductive system

Sunday, August 16

Materials Today BioAug 16

Integrating delivery systems and microenvironmental cues to accelerate clinical translation of cardiac reprogramming

ReviewInterventions

Thursday, August 13

International Journal of Molecular SciencesAug 13

Hepatic SIRT6 Deficiency Accelerates Female-Specific Aging Through SULT1E1-Mediated Estrogen Depletion

Hepatocyte-specific Sirt6 deficiency drives female-biased lifespan reduction and accelerated ageing.

Experiments in miceSIRT6

Wednesday, August 12

Genetics and Molecular ResearchAug 12

MOLECULAR MECHANISMS OF RASAYANA THERAPY FOR HEALTHY AGEING: A SYSTEMATIC REVIEW OF GENOMIC AND EPIGENOMIC EVIDENCE

Systematic reviewInterventions

Tuesday, August 11

Aging and DiseaseAug 11

Metformin: A Promising Candidate for Slowing the Progression of Cardiovascular Aging

ReviewMetformin

Bone ResearchAug 11

Youthfulness of marrow Adipoq⁺ cells maintained by Cbfβ facilitates stem cell-based bone repair

Experiments in miceADIPOQ

Monday, August 10

bioRxivAug 10

Telomere variant sequences encode the genetic blueprint for allele-specific telomere length

Preprint: cohort study in peopleTelomerase and telomere maintenance

Friday, August 7

Preprints.orgAug 7

A Military Veteran with Pulmonary Fibrosis, Hepatic Cirrhosis, Bone Marrow Dysfunction and Shortened Telomeres Found to Have GAVE, a Potential Unsuspected Consequence of Telomere Spectrum Disorder

Preprint: case reportTelomerase and telomere maintenance

BiogerontologyAug 7

SIRT1 in brain aging: molecular mechanisms and therapeutic potential of pharmacological and natural modulators

ReviewInterventions

Monday, August 3

Advances in GerontologyAug 3

Sirtuins as geroprotectors and epigenetic regulators of cell cycle

ReviewSirtuin signaling

Thursday, July 30

Frontiers in AgingJul 30

Immune and DNA repair gene activity differs by sex in seabirds

A cross-sectional study of 16 male and 16 female Scopoli’s shearwaters found sex-linked gene-activity patterns across younger and older adults.A cross-sectional study of 16 male and 16 female Scopoli’s shearwaters found sex-linked gene-activity patterns across younger and older adults.

Cross-sectional studyDNA repair

Wednesday, July 29

Research SquareJul 29

Clinical, cellular, and genomic consequences of a population-enriched SETD1A missense variant

Preprint: cohort study of 3,736 peopleMechanisms

Sunday, July 19

PhysiologyJul 19

Dietary modulation of CMA: implications for cancer prevention and therapy

ReviewMechanisms

International Journal of Ayurveda and Pharma ResearchJul 19

Rasayana Therapy: A Molecular Perspective on Longevity and Telomere Biology-A Narrative Review

ReviewInterventions

Friday, July 10

bioRxivJul 10

Age-related erosion of X chromosome inactivation in human tissues

Preprint: cross-sectional study in peopleMechanisms

Tuesday, July 7

MedicineJul 7

The effect of micronutrient levels on leukocyte telomere length: A Mendelian randomization study

Mendelian randomization in peoplePopulations

Monday, July 6

Journal of Fish BiologyJul 6

Potential factors contributing to extreme longevity in the Greenland shark

ReviewMechanisms

Friday, June 26

NutrientsJun 26

Hospital-supervised diet linked to less DNA damage in obesity

A marker of lasting chromosome damage halved from baseline over three weeks in adults eating about 600 calories daily under hospital supervision.A marker of lasting chromosome damage halved from baseline over three weeks in adults eating about 600 calories daily under hospital supervision.

Non-randomized trial · 53 peopleObesity

BiomoleculesJun 26

Sirtuins in Medicine: Multifaceted Roles in Physiological Processes and Cardiovascular Diseases

ReviewSirtuin signaling

Cell ReportsJun 26

Protein loss shortened lifespan and destabilized DNA in yeast

Experiments in budding yeast cells found that RNA–DNA structures accumulated in repeated ribosomal RNA genes when a protein involved in RNA production was lost.Experiments in budding yeast cells found that RNA–DNA structures accumulated in repeated ribosomal RNA genes when a protein involved in RNA production was lost.

Cell studyMechanisms

Thursday, June 25

BiologyJun 25

Telomere-Associated Proliferative Capacity in Expandable Porcine Hepatocyte-like Progenitor Cells

Experiments in pig cellsInterventions

Tuesday, June 23

Molecular Biology ReportsJun 23

Telomere biology and telomerase regulation across species: evolutionary insights into aging, longevity, and genome stability

ReviewTelomerase and telomere maintenance

Thursday, June 4

European Spine JournalJun 4

A genomic structural equation modelling analysis of the shared genetic architecture of the aging spine

Computational studyMechanisms

Wednesday, June 3

Journal of Biological StudiesJun 3

Targeting the hallmarks of aging: preclinical evidence and molecular mechanisms underlying the therapeutic potential of Centella asiatica (L.) Urban

ReviewInterventions