Fiber density

1. Amyloid-beta increases fiber density in humans (r = 0.34, p < .001).

   “In contrast, Aβ positively predicted FD in striatal, thalamic, midbrain, and cerebellar projection fibers, and in corpus callosum‐genu ( r = 0.34, p <.001).”

   Humansin older adults without dementian = 122

   Centiloid levels predict altered brain microstructure in adults without dementia

   AAIC 2025 abstract·23 Dec 2025

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1. Age is associated with fiber density in humans (p <0.001).

   “increases in the “prefrontal” pathway with age( p <0.001)”

   Humanshippocampus to prefrontal cortex

   Imaging age‐related hippocampal connectivity changes across the adult lifespan in a large‐scale dataset

   AAIC 2025 abstract·25 Dec 2025

1. immune activation pathway PRS is associated with fiber density in humans.

   “p ‐Tau181 moderated the effect of the immune activation pathway on FD, with a negative slope in T+ compared to T‐ individuals”

   Humansin T+ compared to T- individualswhite mattern = 803

   Polygenic pathways shape white matter vulnerability to Alzheimer's disease pathology

   AAIC 2025 abstract·24 Dec 2025

1. clearance pathway PRS is associated with fiber density in humans.

   “Aβ1‐42 moderated the effect of the clearance pathway on FD, with a positive slope in A+ compared to A‐ individuals”

   Humansin A+ compared to A- individualswhite mattern = 803

   Polygenic pathways shape white matter vulnerability to Alzheimer's disease pathology

   AAIC 2025 abstract·24 Dec 2025

1. migration pathway PRS is associated with fiber density in humans.

   “The migration pathway was linked to greater FD and FC primarily in the left hemisphere, aligning with hemispheric dominance”

   Humansnon-demented participantswhite mattern = 803

   Polygenic pathways shape white matter vulnerability to Alzheimer's disease pathology

   AAIC 2025 abstract·24 Dec 2025

1. Phosphorylated tau 181 is associated with fiber density in humans.

   “P‐Tau181 showed both increasing and decreasing effects on FD, indicating a multiphasic relationship.”

   Humansnon-demented participants, adjusting for age, sex, total intracranial volume, and APOE-ε4white mattern = 803

   Polygenic pathways shape white matter vulnerability to Alzheimer's disease pathology

   AAIC 2025 abstract·24 Dec 2025

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1. Sleep apnea is associated with fiber density in humans (p<.05).

   “APOE e4 allele carriage, family history of dementia, higher BMI, and self-reported diagnoses of hypertension and sleep apnea are independently associated with widespread patterns of lower white matter fiber density.”

   Humanswithout dementiawhite mattern = 76

   DEMENTIA RISK FACTORS PREDICT ALTERED WHITE MATTER MICROSTRUCTURE IN A RURAL AGING COHORT

   GSA 2024 abstract·31 Dec 2024

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1. Hypertension is associated with fiber density in humans (p<.05).

   “APOE e4 allele carriage, family history of dementia, higher BMI, and self-reported diagnoses of hypertension and sleep apnea are independently associated with widespread patterns of lower white matter fiber density.”

   Humanswithout dementiawhite mattern = 76

   DEMENTIA RISK FACTORS PREDICT ALTERED WHITE MATTER MICROSTRUCTURE IN A RURAL AGING COHORT

   GSA 2024 abstract·31 Dec 2024

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1. APOE is associated with fiber density in humans (p<.05).

   “APOE e4 allele carriage, family history of dementia, higher BMI, and self-reported diagnoses of hypertension and sleep apnea are independently associated with widespread patterns of lower white matter fiber density.”

   Humanswithout dementiawhite mattern = 76

   DEMENTIA RISK FACTORS PREDICT ALTERED WHITE MATTER MICROSTRUCTURE IN A RURAL AGING COHORT

   GSA 2024 abstract·31 Dec 2024

More on APOE