MechanismsHumans
Polygenic pathways shape white matter vulnerability to Alzheimer's disease pathology
AAIC 2025 Abstract
Abstract
Background: The Alzheimer's disease (AD) field has shifted toward a biological definition based on the deposition of amyloid‐β1‐42 (Aβ1‐42) and phosphorylated‐Tau181 ( p ‐Tau181), yet only a subset of Aβ1‐42‐positive individuals progresses to AD.
The paper
Mario Tranfa, Leonard Pieperhoff, Giuseppe Pontillo, Luigi Lorenzini
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Emma Susanne Luckett, Lyduine Eisa Collij, Tiago Gil Oliveira, Niccoló Tesi, Natàlia Vilor‐Tejedor, André Altmann, Luca Roccatagliata, Matteo Pardini, Pierre Payoux, Pablo Martínez‐Lage, Craig Ritchie, Juan Domingo Gispert, Arturo Brunetti, Henk J. M. M. Mutsaerts, Alle Meije Wink, Frederik Barkhof,Amsterdam University Medical Centers
AAIC 2025 Abstract · 24 Dec 2025 · CC BY
Presented at AAIC 2025
